Synucleinopathies are caused by a novel mutation.
Because they are caused by the abnormal buildup of protein alpha-synuclein into structures termed Lewy bodies and Lewy neurites in the brain, Parkinson's disease and Lewy body dementia are classified as synucleinopathies. In a healthy brain, alpha-synuclein is present in synapses as monomers, which are separate proteins. However, different mutations in the alpha-synuclein gene may cause the protein to clump together and form bigger oligomers and even larger fibrils. Why In Minnesota wastewater, there is more COVID, but the severity is still low. Read this Blog. Multiple variants of the alpha-synuclein gene that cause synucleinopathies have been found and mapped out, with many studies, including work from the Lashuel lab, indicating that the mutations may function via diverse pathways, resulting in the same disease . Despite their rarity, research into these mutations has yielded crucial insights and assisted in the uncovering of several pathways that contribute to neurodege...